Disposable heat exchanger assembly for sterile and aseptic biotechnology and pharmaceutical manufacturing applications

摘要

A disposable heat exchanger system including a sterile disposable bag assembly and sets of modular stainless steel heating/cooling plate assemblies is disclosed. The sterile disposable bags are manifolded together via disposable tubing and are installed and filled in place with cell culture or protein containing process fluid between the stainless steel heating/cooling plates. The stainless steel heating/cooling plates are manifolded together in a modular fashion with stainless steel tubing. Both the sterile disposable bag assembly and the heating/cooling plates are configured to have a serpentine flow pattern. The process fluid within the sterile disposable bag assembly and heating/cooling fluid within the modular stainless steel heating/cooling plates flow in opposite directions in order to provide counter-current flow for efficient heating or cooling.

主权项

1. A disposable heat exchanger assembly, comprising:
a modular stainless steel heating/cooling plate assembly that includes separated plates manifolded together with stainless steel tubing and constructed and arranged in a serpentine flow path for circulation of a heating/cooling fluid; and a customizable, sterile disposable bag assembly that includes a plurality of bags that are manifolded together with disposable tubing and with each bag having a serpentine flow path therethrough; the bags being interspersed between the stainless steel heating/cooling plates, wherein a media to be heated/cooled is in said flow path of said bag assembly and is fully contained within said bag assembly such that it does not contact said heating/cooling plate assembly.