Phenylpyrrole derivative

摘要

Provided are novel compounds that are useful in the prevention or treatment of such diseases as dementia, Alzheimer's disease, attention-deficient hyperactivity disorder, schizophrenia, epilepsy, central convulsion, obesity, diabetes mellitus, hyperlipidemia, narcolepsy, idiopathic hypersomnia, behaviorally induced insufficient sleep syndrome, sleep apnea syndrome, circadian rhythm disorder, parasomnia, sleep related movement disorder, insomnia, and depression, or allergic rhinitis, or pharmaceutically acceptable salts of such compounds. Specifically, there are provided phenylpyrrole compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof:;Formula (I);
[wherein Q refers to a group represented by the following formula (A) or (B):
;

主权项

1. A compound represented by formula (I) [wherein Q refers to a group represented by the following formula (A) or (B): R1 is hydroxyl, C1-C6 alkoxy, or NR1AR1B; R1A and R1B, which may be the same or different, are each a hydrogen atom, C1-C6 alkyl or C3-C7 cycloalkyl, or R1A and R1B are bonded together with the adjacent nitrogen atom to form a 3- to 7-membered saturated heterocyclic ring (the saturated heterocyclic ring being optionally substituted by one or two C1-C6 alkyls); R2 is a hydrogen atom, a halogen atom, or C1-C6 alkyl; n is 1 or 2; R3 is a hydrogen atom, a halogen atom, or C1-C6 alkyl; R4 is C1-C6 alkyl (the C1-C6 alkyl may be substituted by one or two C3-C7 cycloalkyls) or C3-C7 cycloalkyl (the C3-C7 cycloalkyl may be substituted by one or two C1-C6 alkyls); R5 and R6, which may be the same or different, are each C1-C6 alkyl or C3-C7 cycloalkyl, or R5 and R6 are bonded together with the adjacent nitrogen atom to form a 3- to 7-membered saturated heterocyclic ring (the saturated heterocyclic ring being optionally substituted by one or two C1-C6 alkyls)] or a pharmaceutically acceptable salt thereof.