Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response

摘要

In an embodiment of the invention, a frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain tissue biopsy samples. A frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device is narrow and pointed with a hybrid pear shaped diamond facet. Abrasive material can be adhered to the facet.

主权项

1. A device for obtaining a biopsy tissue sample comprising:
(a) a handle including a proximal end and a distal end, where the handle has a principal axis of rotation, wherein the principal axis of rotation bisects the proximal end of the handle and the distal end of the handle; (b) a head with a proximal end and a distal end, where the proximal end of the head is attached to the distal end of the handle; (c) a facet associated with the head with a central portion, an outer portion and a perimeter, where the facet is planar, where the plane of the facet is perpendicular to the principal axis of rotation, where the principal axis of rotation passes through the central portion, where the outer portion is adjacent to the perimeter of the facet; and (d) two or more regions of an abrasive material attached to the facet, where a first region of the abrasive material with a first length of loop abrasive material includes a plurality of fenestrated loops attached to the central portion of the facet and a second region of the abrasive material with a second length of loop abrasive material attached to the outer portion of the facet, where the first length of loop abrasive material is longer than the second length of loop abrasive material, where the plurality of fenestrated loops have a hook end, where a distance from the top of the plurality of fenestrated loops to the bottom of the hood end is less than 20% of the length of the plurality of fenestrated loops.