| 摘要 |
THE PRESENT INVENTION RELATES TO A FORM 1 AND FORM 2 POLYMORPH OF (-)-TRANS-3-(5,6-DIHYDRO-4H-PYRROLO [3,2,1-IJ] QUINOLIN-1-YL)-4-(1H-INDOL-3-YL) PYRROLIDINE- 2,5-DIONE . THE PRESENT INVENTION ALSO RELATES TO (-)-TRANS-3-(5,6-DIHYDRO-4H-PYRROLO [3,2,1-IJ] QUINOLIN-1.YL)-4-(1H-INDOL-3-YL) PYRROLIDINE-2, 5-DIONE COMPOUNDS HAVING A CHIRAL PURITY GREATER THAN 99%, AND METHODS OF PREPARATION OF THESE COMPOUNDS. THE PRESENT INVENTION ALSO RELATES TO PHARMACEUTICAL COMPOSITIONS COMPRISING THESE (-)-TRANS-3-(5,6-DIHYDRO-4H-PYRROLO [3,2,1-IJ] QUINOLIN-1-YL)-4-(1H-INDOL-3-YL)PYRROLIDINE-2,5-DIONE COMPOUNDS. THE PRESENT INVENTION PROVIDES METHODS OF TREATING A CELL PROLIFERATIVE DISORDER, SUCH AS A CANCER, BY ADMINISTERING TO A SUBJECT IN NEED THEREOF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOSITION COMPRISING (-)- TRANS-3-(5,6-DIHYDRO-4H-PYRROLO [3,2,1-IJ) QUINOLONE-1-YL)-4-(1H-INDOL-3-YL) PYRROLIDINE-2, 5-DIONE HAVING A CHIRAL PURITY GREATER THAN 99% OR A FORM 1 AND FORM 2 POLYMORPH OF (-)-TRANS-3-(5,6-DIHYDRO-4H-PYRROLO [3,2,1-IJ) QUINOLIN-1-YL)-4-(1H-INDOL-3-YL) PYRROLIDINE-2,5-DIONE. (FIGURE 1) |
