MSC-SelMQC method for simultaneous mapping of polyunsaturated fatty acids, lactate and choline in high fat tissues

摘要

Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing techniques, magnetic resonance signals of one or more unwanted chemicals (that is, chemicals whose signals are to be filtered out or suppressed) chemicals can be suppressed, so that the signal(s) of a first set of chemicals can be obtained without signals from the one or more unwanted chemicals. Information about and differences between the molecular topologies of the first set of chemicals and the one or more unwanted chemicals can be used to design a sequence that suppresses the one or more unwanted chemicals while allowing acquisition of signal(s) from the first set of chemicals.

主权项

1. A method of detecting magnetic resonance (MR) signals, comprising:
exciting a first set of two or more chemicals into a first set of multiple-quantum (MQ) states of two or more MQ-coherence transfer pathways of the corresponding chemicals; applying a plurality of multiple-quantum coherence (MQC) selection gradient pulses, wherein the plurality of MQC selection gradient pulses suppress signals from a set of chemicals to be filtered out; acquiring signals from the first set of two or more chemicals during a first acquisition period; exciting a second set of chemicals into one or more spin echo pathways; and acquiring signals from the second set of chemicals during the first acquisition period.