| 发明名称 | Targeting intracellular target-binding determinants with intracellular antibodies | ||
| 摘要 | The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target. | ||
| 申请公布号 | US9283272(B2) | 申请公布日期 | 2016.03.15 |
| 申请号 | US201313844318 | 申请日期 | 2013.03.15 |
| 申请人 | The United States of America as represented by the Department of Veterans Affairs | 发明人 | Weisbart Richard H.;Nishimura Robert N. |
| 分类号 | A61K39/00;A61K39/395;C07K16/30;C07K16/44 | 主分类号 | A61K39/00 |
| 代理机构 | Adriano & Associates | 代理人 | Adriano & Associates |
| 主权项 | 1. A method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell, and wherein the second Fv fragment is directed to the Mdm2 oncoprotein, thereby inhibiting the intracellular target. | ||
| 地址 | Washington DC US | ||