| 发明名称 |
MDL-1 ligand |
| 摘要 |
The invention provides methods for modulation interactions between MDL-1 and its binding partner, Gal9. Also provided are methods to screen for modulators of MDL-1/Gal9 interaction. |
| 申请公布号 |
US9284377(B2) |
申请公布日期 |
2016.03.15 |
| 申请号 |
US201514744706 |
申请日期 |
2015.06.19 |
| 申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
Joyce-Shaikh Barbara;Wilson Douglas C.;Cua Daniel J.;LaFace Drake M.;Phillips Joseph H. |
| 分类号 |
C07K16/28;G01N33/50;C07K14/705;A61K39/00 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
Thampoe Immac J.;Su Li |
| 主权项 |
1. A method of depleting a population of T lymphocyte cells comprising contacting the population of T lymphocyte cells with an MDL-1 fusion protein that binds directly or indirectly to a molecule expressed on the T lymphocyte cells wherein the MDL-1 fusion protein comprises an extracellular domain of MDL-1 and a heterologous protein which is an Fc portion of an immunoglobulin molecule. |
| 地址 |
Rahway NJ US |
