System and method for controlling G-protein coupled receptor pathways

摘要

A light-sensitive G-protein coupled receptor includes a light sensitive extracellular domain and a heterologous intracellular domain capable of modulating an intracellular signaling pathway.

主权项

1. A mammalian cell comprising:
a first light-sensitive G-protein coupled receptor, the first GPCR being activated by light having a first wavelength and once activated affecting a first cell signaling pathway, a second light-sensitive G-protein coupled receptor, the second GPCR being activated by light having a second wavelength and once activated affecting a second signaling pathway, the second wavelength being different than the first wavelength and the second signaling pathway being different from the first signaling pathway.