发明名称 |
ácido r-7-(3-aminometil-4-metóxi-imino-3-metil-pirrolidin-1-1il)-1-ciclopropil-6-fluoro-4-oxo-1,4-di-hidro-[1,8]naftiridina-3-carboxílico e sal do ácido aspártico, processo para a preparação dos mesmos e composição farmacêutica que compreende os mesmos para antimicrobiano |
摘要 |
Disclosed herein are R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and L-aspartic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same for antimicrobial. Because the R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and L-aspartic acid salt is more soluble and less toxic and has less side effects as an antimicrobial agent than hydrochloride and the other salts (D-aspartate and phosphate) conventionally used, the salt may be useful for oral and injectable administration. |
申请公布号 |
BR112012001897(A2) |
申请公布日期 |
2016.03.15 |
申请号 |
BR20121101897 |
申请日期 |
2010.07.27 |
申请人 |
ARIMED, INC. |
发明人 |
DONG RACK CHOI;JEI MAN RYU;JIN YANG;SEUNG HWAN KIM;SEUNG-KYOO SEONG;SUE HYE YOON;SUNG JAE PYUN |
分类号 |
A61K31/445;A61P31/00;C07D403/04;C07D487/04 |
主分类号 |
A61K31/445 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|