发明名称 |
Midler og fremgangsmåder til udløsning af anti-tumorimmunrespons |
摘要 |
The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or enhancing an anti-tumor immune response in a subject. These methods comprise: (a) providing a cell population, from a subject or from another source, which comprises CD8+ T cells, (b) reducing Cbl-b activity in the CD8+ T-cells, (c) administering the cells of step (b) to the subject. The invention provides methods for making CD8+ T cells that do not require stimulation through a co-receptor in order for the cell to become activated or proliferated in response to contact via its T cell receptor. Such methods are based upon reducing function of Cbl-b. The invention also provides methods for identifying agents which affect Cbl-b expression or activity. |
申请公布号 |
DK2069381(T3) |
申请公布日期 |
2016.03.14 |
申请号 |
DK20070838099T |
申请日期 |
2007.09.13 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES |
发明人 |
GU, HUA;JANG, IHNKYUNG;HODES, RICHARD;CHIANG, JEFFREY J. |
分类号 |
C12Q1/25;A61K39/00;C12N5/0783;C12N15/113;G01N33/50 |
主分类号 |
C12Q1/25 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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