发明名称 |
POLYNUCLEOTIDES HAVING BIOREVERSIBLE GROUPS |
摘要 |
The disclosure provides methods and compositions for delivering polynucleotides into cells. The disclosure provides transiently protected polynucleotides comprising an anionic charge-neutralizing moiety/group, which may also confer additional functionality. These compounds can enter the cytosol of cells by endocytic or macropinocytic mechanisms. The transient protecting group is bioreversible, i.e., once inside a cell, it is designed to be removed by enzymatic activity or by passive intracellular methods (e.g., changes in pH or reductive environment). |
申请公布号 |
HK1208682(A1) |
申请公布日期 |
2016.03.11 |
申请号 |
HK20150109270 |
申请日期 |
2015.09.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DOWDY, STEVEN F.;MEADE, BRYAN R.;GOGOI, KHIRUD |
分类号 |
C07H;C12N |
主分类号 |
C07H |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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