发明名称 GEL-FORMING SYSTEM FOR REMOVING URINARY CALCULI AND FRAGMENTS THEREOF
摘要 Primarily described are gel-forming systems, consisting of or comprising a composition (A), comprising one or several cationically crosslinkable polymer(s), and a composition (B), comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s) for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, with the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(s) upon contact of composition (A) with composition (B) so that a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, (iii) removing the crosslinked gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are surrounded by it from the urinary tract, more particularly the kidney.
申请公布号 US2016067373(A1) 申请公布日期 2016.03.10
申请号 US201314786810 申请日期 2013.08.22
申请人 FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ;ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG 发明人 GRUNWALD Ingo;RICHTER Katharina;MIERNIK Arkadiusz;SCHOENTHALER Martin
分类号 A61L24/08;A61L24/02 主分类号 A61L24/08
代理机构 代理人
主权项 1. A method for removing at least one of urinary calculi and fragments of urinary calculi from a region of a urinary tract the method comprising the following steps: introducing composition (A) that comprises one or more cationically crosslinkable polymers into the region of the urinary tract that contains at least one of urinary calculi and fragments of urinary calculi, introducing composition (B) that comprises one or more crosslinking agents for crosslinking the one or more cationically crosslinkable polymers into the region of the urinary tract, wherein in response to the composition (A) and the composition (B) coming into contact with each other and under conditions enabling crosslinking of the cationically crosslinkable polymers, a crosslinked gel is formed that partly or fully surrounds at least one of the urinary calculi and fragments of the urinary calculi, and removing the crosslinked gel together with at least one of the urinary calculi and fragments of the urinary calculi.
地址 München DE