INHIBITORS OF THE ENZYME UDP-GLUCOSE: N-ACYL-SPHINGOSINE GLUCOSYLTRANSFERASE

摘要

This invention relates to novel inhibitors of UDP-glucose: N-acyl-sphingosine glucosyltransferase and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of UDP-glucose: N-acyl-sphingosine glucosyltransferase.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein each Y1 is the same and is hydrogen or deuterium; each Y2 is the same and is hydrogen or deuterium; Y3 is hydrogen or deuterium; Y4 is hydrogen or deuterium; each Y5 is the same and is hydrogen or deuterium; each Y6 is the same and is hydrogen or deuterium; and each Y7 is the same and is hydrogen or deuterium; R1 is wherein each X1 is the same and is hydrogen or deuterium; each X2 is the same and is hydrogen or deuterium; each X3 is the same and is hydrogen or deuterium; each X4 is the same and is hydrogen or deuterium; each X5 is the same and is hydrogen or deuterium; each X6 is the same and is hydrogen or deuterium; and each Z is the same and is hydrogen or deuterium; provided that if each Y is hydrogen and each X is hydrogen, then each Z is deuterium.