发明名称 |
A conditional replicating cytomegalovirus as a vaccine for CMV |
摘要 |
The present invention relates to methods of inducing an immune response to cytomegalovirus (CMV) using a genetically modified CMV that is conditionally replication defective. The methods of the invention can be used to treat and/or prevent primary CMV infection, infection due to reactivation of a latent CMV and a super-infection of a different strain of CMV that had been previously encountered. The present invention also relates to a replication defective CMV which has been recombinantly altered to allow for external control of viral replication. Compositions comprising the replication defective CMV are also encompassed by the present invention. |
申请公布号 |
AU2012304783(B2) |
申请公布日期 |
2016.03.10 |
申请号 |
AU20120304783 |
申请日期 |
2012.09.04 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
FU, TONG-MING;WANG, DAI;MEDI, MUNEESWARA BABU |
分类号 |
A61K39/12;A61K48/00;C07H21/04 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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