发明名称 |
Methods and pharmaceutical compositions for treating adverse or deleterious sequellae of traumatic brain injury |
摘要 |
This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic stress disorder, and other adverse consequences depending on the progression of the initial injury, comprising administering to a TBI victim in need thereof a therapeutically-effective amount of an antiglycolytic compound, particularly 2-deoxyglucose (2-DG) or glycolysis-inhibiting analogs thereof. The invention also provides pharmaceutical compositions of 2-DG or glycolysis-inhibiting analogs thereof for use in the methods of the invention. |
申请公布号 |
AU2011285703(B2) |
申请公布日期 |
2016.03.10 |
申请号 |
AU20110285703 |
申请日期 |
2011.08.04 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
HUTCHINSON, ELIZABETH B.;MEYERAND, MARY ELIZABETH;RUTECKI, PAUL A.;SUTULA, THOMAS P. |
分类号 |
A61K31/7004;A61P25/28 |
主分类号 |
A61K31/7004 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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