| 发明名称 |
Compositions and Methods for "Resistance-Proof" SiRNA Therapeutics for Influenza |
| 摘要 |
The present invention relates to compositions and methods for development of resistance-proof siRNA therapeutics for prevention and treatment of influenza viral infections. The compositions include a pharmaceutical composition comprising siRNA molecules that target conserved regions of an influenza virus gene and a pharmaceutically acceptable polymeric carrier. In one embodiment, the polymeric carrier condenses the molecules to form a nanoparticle. |
| 申请公布号 |
US2016068843(A1) |
申请公布日期 |
2016.03.10 |
| 申请号 |
US201314418432 |
申请日期 |
2013.07.07 |
| 申请人 |
Sirnaomics, Inc. |
发明人 |
Lu Patrick Y.;Evans David M.;Xu John J.;Lu Alan Y.;Ge Qing |
| 分类号 |
C12N15/113;A61K9/00;A61K31/713 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising at least two different siRNA molecules and a pharmaceutically acceptable polymeric carrier, wherein one of the at least two different siRNA molecules targets a conserved region of an influenza virus gene and the other of the at least two different siRNA molecules targets a conserved region of a different influenza virus gene. |
| 地址 |
Gaithersburg MD US |
