发明名称 |
CYTOTOXIC BENZODIAZEPINE DERIVATIVES |
摘要 |
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. |
申请公布号 |
WO2016036804(A1) |
申请公布日期 |
2016.03.10 |
申请号 |
WO2015US48064 |
申请日期 |
2015.09.02 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
CHARI, RAVI, V.J.;MILLER, MICHAEL, LOUIS;SHIZUKA, MANAMI |
分类号 |
C07D487/04;A61K31/5513;A61P35/00;C07D519/00;C07K7/02;C07K16/28 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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