发明名称 |
REDUCING INTRON RETENTION |
摘要 |
Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed m RNA transcript to remove a retained intron to produce a fully processed m RNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject. |
申请公布号 |
WO2015193651(A4) |
申请公布日期 |
2016.03.10 |
申请号 |
WO2015GB51756 |
申请日期 |
2015.06.16 |
申请人 |
UNIVERSITY OF SOUTHAMPTON |
发明人 |
VORECHOVSKY, IGOR;KRALOVICOVA, JANA |
分类号 |
C12Q1/68;C12N15/11;C12N15/113 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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