| 摘要 |
Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure;;and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, R2, R3 and R4 are as described herein. In certain embodiments, a compound disclosed herein inhibits ubiquitination, and can be used to treat disease by blocking the degradation of tumor suppressors. |
| 主权项 |
1. A compound having structural formula (I),or a pharmaceutically acceptable salt, prodrug or N-oxide thereof, or solvate or hydrate thereof,wherein
R1 is -hydrogen, —(C1-C6 haloalkyl), —Y—(C1-C6 haloalkyl), —Y—(C0-C6 alkyl)-Ar, —Y—(C0-C6 alkyl)-Het, —Y—(C0-C6 alkyl)-Cak, —Y—(C0-C6 alkyl)-Hca, -halogen, —NO2 or —CN,
wherein Y is O, S, N(R5), and R5 is -hydrogen or —(C1-C6 alkyl); R2 is -hydrogen, —(C1-C6 alkyl), —(C1-C6 haloalkyl), —Y—(C1-C6 alkyl), —Y—(C1-C6 haloalkyl), -halogen, —NO2 or —CN;
wherein Y is O, S, N(R5), and R5 is -hydrogen or —(C1-C6 alkyl); R3 is -hydrogen, —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, -halogen, —NO2 or —CN; and R4 is —(C1-C6 alkyl), —(C1-C6 haloalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het or —(C0-C6 alkyl)-Cak, wherein
each Ar (aryl), Het (heteroaryl), Cak (cycloalkyl), Hca (heterocycloalkyl),alkyl, and haloalkyl is optionally substituted, provided that: at least one of R1 and R3 is not hydrogen, and the compound is not: N-(5-bromoquinolin-8-yl)-4-methylbenzenesulfonamide N-(6-chloroquinolin-8-yl)benzenesulfonamide; N-(5,7-dichloroquinolin-8-yl)-4-methylbenzenesulfonamide; N-(5,7-dichloroquinolin-8-yl)-2,4,6-trimethylbenzenesulfonamide; N-(6-fluoroquinolin-8-yl)benzenesulfonamide; N-(5-chloro-6-fluoroquinolin-8-yl)benzenesulfonamide; N-(6-(trifluoromethoxy)quinolin-8-yl)benzenesulfonamide; 2,6-difluoro-N-(6-fluoroquinolin-8-yl)benzenesulfonamide; 4-chloro-2-fluoro-N-(6-fluoroquinolin-8-yl)benzenesulfonamide; N-(6-fluoroquinolin-8-yl)pyridine-3-sulfonamide; N-(5,6-difluoroquinolin-8-yl)benzenesulfonamide; N-(7-chloroquinolin-8-yl)benzenesulfonamide; N-(6-(trifluoromethoxy)quinolin-8-yl)-6-(trifluoromethyl)pyridine-3-sulfonamide; N-(6-(trifluoromethoxy)quinolin-8-yl)pyridine-2-sulfonamide; N-(6-fluoroquinolin-8-yl)pyridine-3-sulfonamide; N-(6-(trifluoromethoxy)quinolin-8-yl)pyridine-3-sulfonamide; 6-cyano-N-(6-(trifluoromethoxy)quinolin-8-yl)pyridine-3-sulfonamide; 6-cyano-N-(6-fluoroquinolin-8-yl)pyridine-3-sulfonamide; N-(6-bromoquinolin-8-yl)benzenesulfonamide; N-(5-chloroquinolin-8-yl)benzenesulfonamide; N-(5-bromoquinolin-8-yl)benzenesulfonamide; N-(5,7-dichloroquinolin-8-yl)-4-methylbenzenesulfonamide; N-(5,7-dichloroquinolin-8-yl)-2,4,6-trimethylbenzenesulfonamide; 2,4-dichloro-N-(5-chloroquinolin-8-yl)benzenesulfonamide; N-(5-chloroquinolin-8-yl)pyridine-3-sulfonamide; 2-amino-N-(5-chloroquinolin-8-yl)-4-methylbenzenesulfonamide; N-(5-chloro-6-fluoroquinolin-8-yl)benzenesulfonamide; N-(5,6-difluoroquinolin-8-yl)benzenesulfonamide; N-(5-fluoroquinolin-8-yl)benzenesulfonamide; N-(5-morpholinoquinolin-8-yl)benzenesulfonamide; N-(5-bromoquinolin-8-yl)-5-(2-(methylthio)pyrimidin-4-yl)thiophene-2-sulfonamide; N-(5-bromoquinolin-8-yl)-5-(oxazol-5-yl)thiophene-2-sulfonamide; or N-(5-bromoquinolin-8-yl)-4-(2-methylpyrimidin-4-yl)benzenesulfonamide. |
