摘要 |
A method for inhibiting activity of the human androgen receptor in a cell, and a method for treating prostate cancer in a subject in need thereof, using a molecule which specifically inhibits interaction of amino acids 433-438 of the N-terminal domain of the receptor with the RAP74 subunit of TFIIF. A method of inhibiting androgen receptor activity in a cell, and a method for treating prostate cancer in a subject in need thereof, using an inhibitor of the phosphorylation of one or more residues of the N-terminal domain of the androgen receptor selected from the group consisting of: Ser422, Ser424, Ser426, Ser430, Ser431, Ser432, Thr435 and Thr438. A method of diagnosing a subject having, or at risk of having, castration-resistant prostate cancer, comprising determining the phosphorylation status of one or more of residues Ser422, Ser424, Ser426, Ser430, Ser431, Ser432, Thr435 and Thr438. |
申请人 |
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA);INSTITUCIO CATALANA DE RECERCA I ESTUDIS ADVANCATS;UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN;UNVERSITAT DE BARCELONA |
发明人 |
SALVATELLA, XAVIER;DE MOL, EVA;BERTONCINI, CARLOS, W.;PHANG, CHRISTOPHER, T.W.;MCEWAN, IAIN, J.;RIERA, ANTONI |