主权项 |
1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I: wherein: R1 is selected from the group consisting of -heteroaryl(R4)q and -heterocyclyl(R5)h; R2 is selected from the group consisting of H and halide; R3 is selected from the group consisting of -heteroaryl(R6)q, -heterocyclyl(R7)h, and -aryl(R8)k; each R4 is one substituent attached to the heteroaryl and is independently selected from the group consisting of halide, —(C1-6 alkyl), —(C1-4 alkylene)pheterocyclyl(R9)h, —(C1-4 alkylene)pcarbocyclyl(R10)j, —(C1-4 alkylene)paryl(R11)k, —NHC(═O)R12, —NR13R14, —(C1-6 alkylene)NR15R16, and —OR22; each R5 is one substituent attached to the heterocyclyl and is independently selected from the group consisting of —(C1-4 alkyl), halide, —CF3, and —CN; each R6 is one substituent attached to the heteroaryl and is independently selected from the group consisting of —(C1-6 alkyl), halide, —CF3, —OCH3, —CN, and —C(═O)R17; each R7 is one substituent attached to the heterocyclyl and is independently selected from the group consisting of —(C1-6 alkyl), halide, —CF3, —CN, and —OCH3; each R8 is one substituent attached to the aryl and is independently selected from the group consisting of —(C1-6 alkyl), halide, —CF3, —CN, —OCH3, —(C1-6 alkylene)pNHSO2R17, —NR13(C1-6 alkylene)NR13R14, —(C1-6 alkylene)pNR13R14, and —OR25; each R9 is one substituent attached to the heterocyclyl and is independently selected from the group consisting of amino, —(C1-4 alkyl), halide, —CF3, and —CN; each R10 is one substituent attached to the carbocyclyl and is independently selected from the group consisting of —(C1-4 alkyl), halide, —CF3, and —CN; each R11 is one substituent attached to the aryl and is independently selected from the group consisting of —(C1-4 alkyl), halide, —CF3, and —CN; each R12 is independently selected from the group consisting of —(C1-9 alkyl), -heteroaryl(R18)q, -aryl(R19)k, —CH2aryl(R19)k, -carbocyclyl(R20)j, —CH2carbocyclyl(R20)j, —(C1-4 alkylene)pNR23R24, -heterocyclyl(R21)h, and —CH2heterocyclyl(R21)h; each R13 is independently selected from the group consisting of H and —(C1-6 alkyl); each R14 is independently selected from the group consisting of H, —(C1-6 alkyl), —CH2aryl(R19)k, and —CH2carbocyclyl(R20)j; each R15 is independently selected from the group consisting of H and —(C1-6 alkyl); each R16 is independently selected from the group consisting of H, —(C1-6 alkyl), —CH2aryl(R19)k, and —CH2carbocyclyl(R20)j; each R17 is a —(C1-6 alkyl); each R18 is one substituent attached to the heteroaryl and is independently selected from the group consisting of —(C1-4 alkyl), halide, —CF3, and —CN; each R19 is one substituent attached to the aryl and is independently selected from the group consisting of —(C1-4 alkyl), halide, —CF3, and —CN; each R20 is one substituent attached to the carbocyclyl and is independently selected from the group consisting of —(C1-4 alkyl), halide, —CF3, and —CN; each R21 is one substituent attached to the heterocyclyl and is independently selected from the group consisting of —(C1-4 alkyl), halide, —CF3, and —CN; R22 is selected from the group consisting of H, —(C1-6 alkyl), —(C1-4 alkylene)pheterocyclyl(R21)h, —(C1-4 alkylene)pcarbocyclyl(R20)j, —(C1-4 alkylene)paryl(R19)k, and —(C1-6 alkylene)pNR23R24; each R23 is independently selected from the group consisting of H and —(C1-6 alkyl); each R24 is independently selected from the group consisting of H and —(C1-6 alkyl); R25 is selected from the group consisting of H, —(C1-6 alkyl), —(C1-4 alkylene)pheterocyclyl(R21)h, and —(C1-6 alkylene)pNR23R24; each p is independently 0 or 1; each q is independently 0 to 4; each h is independently 0 to 10; each k is independently 0 to 5; and each j is independently 0 to 12. |