发明名称 COMPOUNDS FOR TREATMENT OF PAIN
摘要 The invention is directed to novel compounds, formulations containing said compounds or pharmaceutically acceptable salts thereof which are suitable for administration to a patient.
申请公布号 US2016068537(A1) 申请公布日期 2016.03.10
申请号 US201414785551 申请日期 2014.04.16
申请人 BIO PHARMA WORKS 发明人 Volkmann Robert;Marfat Anthony;Cornelius Peter;Zagouras Panayiotis;Nelson Frederick Raymond;Fliri Anton Franz Joseph
分类号 C07D489/04;C07C59/08;C07C229/58;C07C59/255;C07C53/126;C07D491/052;C07J9/00;C07C53/10 主分类号 C07D489/04
代理机构 代理人
主权项 1. A compound of the formulawherein R1 is CHR3O(C═O)OR4, CHR3O(C═O)R5, CHR3O(C═O)NR5R6, CHR3O(C═O)CHR7NR5R6, CHR3O(C═O)CHR7NH((C═O)CHR7NH)nH, CHR3R8, CHR3O(C═O)CR4R5OR6, CHR3O(C═O)O(CH2)nNR4R5, CHR3O(C═O)O(CH2)nCO2R4, CHR3O(C═O)(CH2)nNR4R5, CHR3O(C═O)(CH2)nCO2R4, R2 is H or CH3(C═O); R3 is H or optionally substituted alkyl; wherein said substituents are independently selected from the group OR2 and (C═O)OR4; R4 is optionally substituted alkyl, cycloalkyl, phenylalkyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, wherein said substituents are independently (CH2)nCO2alkyl; R5 is H or R4 R6 is H or R4; R7 is H or R4; R8 is 4-isoxazoyl; wherein n is an integer from 1-12; A is an anion selected from the group consisting of: Br−, cl−, I−, R7CO2−, H2PO4−, NO3−, Etodolate, Mefenamate, Urosodeoxycholate and R6SO3.
地址 Goton CT US