THIAZOLES AND USES THEREOF

摘要

This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

主权项

1. A compound having formula (A), or a pharmaceutically acceptable salt thereof, wherein, RA is selected from the group consisting of C1-C6alkyl, C1-C6alkoxyalkyl, cyanoC1-C8alkyl, C1-C6haloalkyl, 1,3-thiazol-2-yl and 1,3,4-thiadiazol-2-yl; RB is selected from the group consisting of RC is selected from the group consisting of:
branched-C4-C8alkyl, branched-C3-C8haloalkyl and —C(R1aR1b)—O—C1-C6alkyl, wherein R1a is hydrogen or C1-C6alkyl, and R1b is C1-C6alkyl;C5-C7cycloalkyl, wherein the C5-C7cycloalkyl is optionally substituted with 1 or 2 substituents selected from the group consisting of C1-C6alkyl, C1-C6haloalkyl and halogen;phenyl or 5- or 6-membered heteroaryl, wherein the phenyl or 5- or 6-membered heteroaryl are each independently optionally substituted with 1, 2 or 3 substituents selected from the group consisting of C1-C4alkyl, C1-C4alkoxy, haloC1-C4alkyl, haloC1-C4alkoxy, halogen and phenyl;monocyclic C6-C7cycloalkylC1-C3alkyl or bicyclic C8-C10cycloalkylC1-C3alkyl, wherein the monocyclic C5-C7cycloalkyl of monocyclic C5-C7cycloalkylC1-C3alkyl and the bicyclic C6-C10cycloalkyl of bicyclic C8-C10cycloalkylC1-C3alkyl are each independently optionally substituted with 1 or 2 substituents selected from the group consisting of C1-C6alkyl, C1-C8alkoxy, C1-C8haloalkyl, C1-C6haloalkoxy and halogen;  wherein the cyclic ether group is optionally substituted with 1, 2 or 3 substituents selected from the group consisting of C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, and halogen, and wherein m is 1, 2 or 3 and n is 1, 2 or 3;
phenylC1-C3alkyl, wherein the phenyl of phenylC1-C3alkyl is optionally substituted with 1, 2 or 3 substituents selected from the group consisting of C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, haloC1-C6alkoxy, cyano and halogen;5- or 6-membered heteroarylC1-C3alkyl, wherein the 5- or 6-membered heteroaryl of 5- or 6-membered heteroarylC1-C3alkyl is optionally substituted with 1, 2 or 3 substituents selected from the group consisting of C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, cyano, halogen and phenyl, and wherein said phenyl is optionally substituted with 1, 2 or 3 substituents selected from the group consisting of C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, haloC1-C6alkoxy, cyano, and halogen; and  wherein
Ra and Rb are at each occurrence independently selected from the group consisting of hydrogen and C1-C6alkyl, orRa and Rb are taken together with the carbon atom to which they are attached to form a cyclopropyl, and whereinp is 0, 1 or 2;q is 1 or 2;r is 1 or 2; ands is 0 or 1; RD is hydrogen or phenyl; RE is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of C1-C6alkyl, C1-C6haloalkyl and halogen; RF is selected from the group consisting of C1-C6alkyl; C1-C8alkoxy; haloC1-C6alkyl; haloC1-C6alkoxy; and 5-membered or 6-membered heteroaryl optionally substituted with a substituent selected from the group consisting of C1-C4alkyl, C5-C4alkoxy, C1-C4haloalkyl, C8-C4haloalkoxy and halogen; RG is selected from the group consisting of hydrogen, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, C1-C6haloalkoxy and halogen; and Y and Z are each independently selected from the group consisting of CH or N; wherein the C1-C3alkyl of monocyclic C1-C7cycloalkylC1-C3alkyl, bicyclic C1-C10cycloalkylC1-C3alkyl, phenylC1-C3alkyl, or 5- or 6-membered heteroarylC-C3alkyl is optionally substituted with a methyl or a cyclopropyl, wherein one atom of the cyclopropyl is an atom on the C1-C3alkyl chain.