发明名称 |
IgG STIMULATED REMYELINATION OF PERIPHERAL NERVES |
摘要 |
IgG STIMULATED REMYELINATION OF PERIPHERAL NERVES [00225] The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival. |
申请公布号 |
AU2016201137(A1) |
申请公布日期 |
2016.03.10 |
申请号 |
AU20160201137 |
申请日期 |
2016.02.23 |
申请人 |
BAXALTA INCORPORATED;BAXALTA GMBH |
发明人 |
TZEKOVA, NEVENA;HARTUNG, HANS-PETER;HERMANN, CORINNA;REIPERT, BIRGIT MARIA;SCHWARZ, HANS-PETER;EHRLICH, HARTMUT;BUNK, SEBASTIAN;KUERY, PATRICK |
分类号 |
A61K39/395;A61P35/02 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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