Micromirs

摘要

The present invention relates to very short heavily modified oligonucleotides which target and inhibit microRNAs in vivo, and their use in medicaments and pharmaceutical compositions. Ceaivage position 5-bindingpocket seed 1 2 4 5 > 7 41 11 _2 M 14 0 16 13 19 23 21 22 RiSC 7merseedmrn 8mer seedmer I crcRNA V, V V V V v 9rLNA position lSmer seedmer N MAR -1Z2 l A AC A C T C a Figure 1 1,8 1,6 1,4 1,2 1 -- control n IOmm2I 0,8 0,6 0,4 0,2 OnM 1 nM 5nM 10 nM 25 nM 50 nM OnM 1 nM 5nM 10 nM 25 nM 50 nM SEQID#3204 SEQID #3205 Figure 2