AUTOMATED BIOREACTOR SYSTEM, SYSTEM FOR AUTOMATICALLY IMPLEMENTING PROTOCOL FOR DECELLULARIZING ORGAN, AND WASTE DECONTAMINATION SYSTEM

摘要

An automated bioreactor system (100) for decellularizing an organ (5) such as a lung includes a main chamber (15) for containing the organ and at least one reagent chamber (11) containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump (21) drives the flow of the reagent. A perfusion pressure sensor (25) detects a pressure of the flowing reagent. A control system (50) controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system (30) may also be provided.