| 发明名称 |
METHODS FOR STIMULATING ANTIGEN-SPECIFIC T CELL RESPONSES |
| 摘要 |
The present invention relates to methods for stimulating antigen-specific T cell responses. In particular, the invention relates to a method for stimulating antigen (Ag)-specific T cell responses in a blood sample or PBMC sample isolated from a subject comprising the step consisting in culturing said blood or PBMC sample in a appropriate culture medium which comprises an amount of IL-1beta and an amount of a least one antigen. |
| 申请公布号 |
US2016068808(A1) |
申请公布日期 |
2016.03.10 |
| 申请号 |
US201414785924 |
申请日期 |
2014.04.22 |
| 申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RESEARCHE MÉDICALE) ;UNIVERSITÉ DE PARIS - SUD |
发明人 |
MALLONE Roberto;AFONSO Georgia |
| 分类号 |
C12N5/0783;G01N33/569 |
主分类号 |
C12N5/0783 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for stimulating antigen (Ag)-specific T cell responses in a blood sample or PBMC sample isolated from a subject comprising the step of
culturing said blood or PBMC sample in an appropriate culture medium which comprises an amount of IL-1β and an amount of a least one antigen wherein the culture medium does not contain a differentiating agent selected from the group consisting of Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF), IL-4 and FMS-like tyrosine kinase 3 (Flt-3) ligand. |
| 地址 |
Paris FR |
