| 摘要 |
Embodiments of the present invention provide for efficient methods and processes for preparing ionic amino acid esters from a specific synthesis route. The disclosed embodiments consist of a single reaction step: reacting a natural or synthetic unprotected amino acid with an aliphatic, branched or aromatic fatty alcohol of even or odd number of carbon atoms from 6 to 20 with or without unsaturation(s), in stoichiometric amounts, in the presence of an organic acid (HX) like carboxylate, mesylate, tosylate or sulfonate, employed as catalyst and under conventional heating (CC) of 1 to 3 hours at a temperature in the range of approximately 60 to 150° C. and pressure the range of approximately 0 to approximately 250 psi; the product obtained is cooled and recrystallized from ethanol. |
| 主权项 |
1. A process for preparing ionic amino acid esters, comprising the following synthesis route: wherein: R1 and R2 represent aliphatic or branched chains of alkyl groups, functionalized alkyl or alkoxy, R1 represents an aromatic or heterocyclic group of 1 to 10 carbon atoms, preferably 1 to 6 carbon atoms to give the corresponding amino acid, R2 represents an aromatic, branched, or heterocyclic chain of 6 to 20 aliphatic carbon atoms with or without unsaturation(s), preferably 8 to 18 carbon atoms, and X represents a moiety of the organic acid like carboxylic, mesylate, or sulfonate including tosylate, preferably mesylate and tosylate; and consisting of a single reaction step:
a) reacting a natural or synthetic unprotected amino acid (1) with an aliphatic, branched or aromatic fatty alcohol (2) of even or odd number of carbon atoms from 6 to 20 with or without unsaturation(s), in stoichiometric amounts, in the presence of an organic acid (HX) like carboxylate, mesylate, tosylate or sulfonate among others, employed as catalyst and under conventional heating (CC) of 1 to 3 hours at a temperature of 60 to 150° C. and pressure of 0 to 250 psi; the product obtained is cooled and recrystallized from ethanol. |
