| 发明名称 |
ANTI-IL-17 ANTIBODIES, METHODS OF THEIR PRODUCTION AND APPLICATION |
| 摘要 |
FIELD: bioengineering.SUBSTANCE: invention proposes a monoclonal antibody and its antigen-bonding fragment that can specifically bond with a human IL-17A and are described by CDR sequences. Besides, it discloses a DNA, encoding the antibody or its antigen-bonding fragment; an expression vect∨ a cellular line and the production of the antibody or its fragment. Also, it proposes a pharmaceutical composition and the method of treatment a mediated IL-17A disease or dysfunction.EFFECT: stable blocking of IL-17A under thermal stress conditions, increased period of semi-ejection from blood.27 cl, 16 dwg, 1 tbl, 15 ex |
| 申请公布号 |
RU2577228(C2) |
申请公布日期 |
2016.03.10 |
| 申请号 |
RU20140109854 |
申请日期 |
2014.03.14 |
| 申请人 |
ZAKRYTOE AKTSIONERNOE OBSHCHESTVO "BIOKAD" |
发明人 |
ULITIN ANDREJ BORISOVICH;EVDOKIMOV STANISLAV RUDOLFOVICH;SOLOVEV VALERIJ VLADIMIROVICH;CHERNYKH JULIJA SERGEEVNA;GONCHAROVA OLGA VLADIMIROVNA;KORZHAVIN DMITRIJ VALEREVICH;CHERNOVSKAJA TATJANA VENIAMINOVNA;IVANOV ROMAN ALEKSEEVICH;MOROZOV DMITRIJ VALENTINOVICH |
| 分类号 |
C07K16/24;A61K39/395;A61P37/06;C12N5/10;C12N15/13;C12N15/63 |
主分类号 |
C07K16/24 |
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