| 摘要 |
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/126904 Al 29 August 2013 (29.08.2013) W I PO I P CT (51) International Patent Classification: (74) Agent: PARENT, Annette, S.; Morgan, Lewis & Bockius C07K16/06 (2006.01) A61K35/16 (2006.01) LLP, One Market, Spear Street Tower, San Francisco, CA A61K 39/395 (2006.01) C07K 1/30 (2006.01) 94105 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2013/027681 kind of national protection available): AE, AG, AL, AM, .) . AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filng Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, 25 February 2013 (25.02.2013) DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (26) Publication Language: English ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (30) Priority Data: NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, 61/602,488 23 February 2012 (23.02.2012) US RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (71) Applicants: BAXTER INTERNATIONAL INC. ZM, ZW. [US/US]; One Baxter Parkway, Deerfield, IL 60015 (US). BAXTER HEALTHCARE S.A. [CH/CH]; Thurgauer- (84) Designated States (unless otherwise indicated, for every strasse 130, CH-8152 Glattpark (opfikon) (CH). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (72) Inventors; and UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicants (for US only): BRUCKSCHWAIGER, Leo- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, pold [AT/AT]; Herminengasse 5/14, A-1020 Vienna (AT). EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, GUNDINGER, Thomas [AT/AT]; Barawitzkagasse 4/11, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, A- 1190 Vienna (AT). NUERNBERGER, Julia [AT/AT]; TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Donaufelderstr. 52/45, A-1210 Vienna (AT). ML, MR, NE, SN, TD, TG). TESCHNER, Wolfgang [DE/AT]; Gestettengasse 19/14, Published A-1030 Vienna (AT). SCHWARZ, Hans-peter [AT/AT]; Weimarer Strasse 76, A-1 180 Vienna (AT). - with international search report (Art. 21(3)) (54) Title: FRACTION I-IV-1 PRECIPITATION OF IMMIJNOGLOBINS FROM PLASMA Cryo Poor Plasma Fractionation 1+11+lll+1V1 25% pH 5.5 readjusted 1+ll+111+lVl Precipitate l+11-l+IV1 Supernatant Resuspension of the precipitate Aerosil treatment and filtration IV4 Precipitate IV4 Supernatant Filtrate Filtercake lgG,lgA,lgM AlPI and Factor H Albumin (57) Abstract: Among other aspects, the present invention provides methods for the manufacture of blood protein compositions O from pooled plasma. In one embodiment, the invention provides an alcohol fractionation scheme that allows for significant increases in the yield of blood proteins purified from the starting plasma sample. In a specific embodiment, a method for fractionating pooled plasma is provided, the method comprising an initial low pH, high alcohol precipitation step. The present invention also provides pharmaceutical compositions of therapeutic blood proteins. |
