| 摘要 |
Agents intended for prevention and treatment of diseases of the joints and methods of their application are proposed. The group of the inventions pertains to creation of the agents intended for prevention and treatment of diseases of the joints, in particular arthritis, osteoarthritis, and osteochondrosis of the spine, as well as other conditions and diseases accompanied by pain and joint lesions and methods of their application. The invention pertains to the agents intended for prevention and treatment of diseases of the joints, comprising a mixture of peptides Lys-Asp-Glu, Ala-Asp-Glu, Asp-Glu-Gly and chondroitin and/or its salts and/or glucosamine and/or its salts as well as methods of their application enabling the achievement of a synergistic effect associated with the combined use of the peptide combination and chondroitin and/or its salts and/or glucosamine and/or its salts. Application of the compositions is accompanied by a pronounced analgesic effect and results in positive changes in the dynamics of clinical and biochemical parameters, contributes to normalization of the morphostructure of joint tissues, including the cytoarchitectonics of cartilaginous tissue accompanied by decrease in the number of chondrocytes undergoing apoptosis, particularly its final stages, and exerts a favorable effect on the metabolic processes that occur in chondrocytes via activation of the synthetic processes and normalization of the biopolymer composition of cartilaginous matrix. |
