HUMAN MONOCLONAL ANTIBODY TO PROGRAMMED DEATH 1(PD-1) AND METHOD FOR TREATING CANCER USING ANTI-PD-1 ANTIBODY ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS

摘要

PROBLEM TO BE SOLVED: To provide isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to programmed Death 1 (PD-1) with high affinity.SOLUTION: There are provided isolated human monoclonal antibodies cross-competing for binding to a reference antibody including human heavy chain and light chain variable regions composed of specific amino acid sequences and PD-1, or a binding portion thereof. A method for detecting PD-1 is provided and various diseases including cancer and infectious diseases can be treated by preparing immunocomplexes, bispecific molecules and pharmaceutical compositions containing the antibodies. Furthermore, hyperproliferative diseases such as cancer can also be treated by a combination immunotherapy such as a combination of anti-CTLA-4 and anti-PD-1 antibodies. Adverse events related to the treatment with each of such antibodies are altered.SELECTED DRAWING: None