| 摘要 |
Described herein are enopeptin analogs of Formula (I) or (II): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, R5, R6, m, X, RXa, and Y are as defined herein. Such compounds have been found to exhibit antibacterial activity, to competatively interfere with the bacterial efflux pump, and/or to potentiate the activities of other anti-bacterial agents, such as an ADEP4, against bacteria that are not susceptible due to efflux pumps. Further provided are a methods of such compounds treatment and use. |
