Modified Proteins and Methods of Use Thereof

摘要

This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.

主权项

1. A modified protein comprising at least 4 cationic residues, wherein the at least 4 cationic residues are displayed on at least 3 α-helical cationic faces.