| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to heterocyclic compounds of formula Ib and its pharmaceutically acceptable salts, wherein X, Y and Z represent CH; o is equal to 1; n is equal to 0; m is equal to 1 or 2; A represents C=O; W represents NH; in each specific case, Ris independently specified in a group consisting of C-Calkyl; in each specific case, Ris independently specified in a group consisting of halogen, C-Calkyl optionally substituted by halogen; OR, -NO, heteroaryl representing pyridyl; in each specific case, Ris independently specified in a group consisting of C-Calkyl and C-Chalogenalkyl; Rrepresents a fragment specified in a group consisting ofwherein m' is equal to 0, 1, 2, 3 or 4; in each specific case, Ris independently specified in a group consisting of hydrogen and C-Calkyl; in each specific case, Ris independently specified in a group consisting of hydrogen, C-Calkyl optionally substituted by ORgroup, heterocyclyl representing morpholinyl, or by hydroxyl; C-Ccycloalkyl, C-Chalogenalkyl, hydroxyl, -OR, C(O)R, -C(O)N(R), phenyl optionally substituted by halogen, -N(R)C(O)Rgroup or ORgroup; benzyl optionally substituted by halogen or ORgroup; in each specific case, Ris independently specified in a group consisting of hydrogen, C-Calkyl; phenyl optionally substituted by halogen, C-Chalogenalkyl or ORgroup, benzyl optionally substituted by halogen; in each specific case, Ris independently specified in a group consisting of hydrogen, C-Calkyl, C-Chalogenalkyl, C-Ccycloalkyl, phenyl substituted by halogen or ORgroup. The invention also refers to specific compounds, using the above compounds, a pharmaceutical composition based on the compound of formulaEFFECT: activity of certain known compounds has been examined, and the new compounds possessing inhibitory activity on mycobacterial growth have been produced.10 cl, 3 dwg, 2 tbl, 3 ex |
