| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a compound of structural formulahaving FGFR kinase inhibiting activity. In formula (I) Rare identical or different from each other, and each is C-Calkyl; Xand Xare independently N or CH; Ris hydrogen, C-Calkynyl, -C(=O)OR, -C(=O)N(R)(R), hydroxy-C-Calkyl, di(C-Calkyl)amino-C-Calkkyl or a monocyclic or bicyclic C-Cheteroaryl group containing 1-3 identical or different heteroatoms selected from a nitrogen, oxygen and sulphur atom, optionally containing R; and Ris C-Calkyl or di(C-Calkyl)amino-C-Calkyl; Z is -C(R)=C(R)(R) or -C≡C-R; Rand Rare identical or different from each other, and each is hydrogen, C-Calkyl, C-Ccycloalkyl, di(C-Calkyl)amino-C-Calkyl or C-Calkoxy-C-Calkyl; l is an integer from 0 to 3; m is an integer from 1 to 3; and n is an integer from 0 to 2. Values of radicals Y, R-Rare given in the claim. The invention also relates to a pharmaceutical composition containing said compound, an anti-tumour agent and a tumour treatment method.EFFECT: improved properties of compounds.15 cl, 5 tbl, 73 ex |
