| 摘要 |
The invention comprises compounds of the general formula: <FORM:0850333/IV(b)/1> wherein when n is 1, Y represents a diethylamino, piperidino, 1, 2, 5, 6-tetrahydro-pyridino or morpholino group and Z represents a piperidino (except where Y is diethylamino or piperidino), morpholino, 1, 2, 5, 6-tetrahydro-pyridino, 3-methyl-piperidino, 4-methyl-piperidino or pyrrolidino group; and when N is 2, Y represents a diethylamino, morpholino or piperidino group and Z represents a piperidino or 1, 2, 5, 6-tetrahydro-pyridino group; and their acid-addition and, when n is 2, their quaternary ammonium derivatives. The compounds may be prepared by condensing compounds of the formula: <FORM:0850333/IV(b)/2> where Hal represents a halogen atom, with secondary amines of the formula ZH: and, if desired, converting the products into their acid-addition or quaternary ammonium salts. The products are spasmolytic agents. a -Phenyl-a -halogeno-acetic esters of the second general formula above are prepared by esterifying appropriate amino alcohols with a -phenyl-a -halogeno-acetic acid halide, and the said amino alcohols are prepared by treating chlorohydrin or the acetate of 2-(21-chloro-ethoxy)-ethanol, as appropriate, with HY. |
