| 摘要 |
Provided is a method of producing an ether compound which is useful for production of a phosphoramidite of a nucleotide and represented by chemical formula (3). In chemical formula (3), R represents an alkyl group having 1-6 carbon atoms. The method of the present invention comprises a step A in which a compound represented by chemical formula (1) reacts with metal alkane thiolate having 1-6 carbon atoms in 2-methoxyethanol, wherein n is an integral of 0-5, X is a halogen atom, an alkyl group, a cyano group, a nitro group, or a trifluoromethyl group having 1-3 carbon atoms; a step B in which an organic layer is separated by adding a hydrocarbon solvent having 5-8 carbon atoms and water to a resultant mixture obtained in the step A; a step C in which bis(alkylthio)ether is generated by distilling the solvent from the organic layer obtained in the step B; and a step D in which the bis(alkylthio)ether obtained in the step C reacts with a halogenating agent and 2-cyanoethanol in an ether solvent. |
