发明名称 |
METAL COMPLEXES AND THEIR FLUORINATION |
摘要 |
A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging. |
申请公布号 |
EP2991688(A1) |
申请公布日期 |
2016.03.09 |
申请号 |
EP20140720628 |
申请日期 |
2014.05.02 |
申请人 |
GE HEALTHCARE UK LIMITED;UNIVERSITY OF SOUTHAMPTON |
发明人 |
BHALLA, RAJIV;REID, GILL;LEVASON, WILLIAM |
分类号 |
A61K51/08 |
主分类号 |
A61K51/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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