发明名称 |
OLIGONUCLEOTIDE |
摘要 |
The present invention provides an oligonucleotide having improved affinity for AG02, and the like. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X 1 is an oxygen atom or the like, R 1 is formula (IIA) (wherein R 5A is halogen or the like, and R 6A is a hydrogen atom or the like) or formula (IVA) (wherein Y 3A is a nitrogen atom or the like, and Y 4A is CH or the like), or the like, R 2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R 3 is a hydrogen atom or the like} at the 5' end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3. |
申请公布号 |
EP2891717(A4) |
申请公布日期 |
2016.03.09 |
申请号 |
EP20130833206 |
申请日期 |
2013.09.02 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
SHINOHARA, FUMIKAZU;MAKINO, ASANA;YAMAMOTO, JUNICHIRO;OASHI, TAIJI;SUZUKI, MICHIHIKO;SAITO, JUN-ICHI;NAKAJIMA, TAKAHIRO;NISHIKAWA, TOMOYUKI;NAKOJI, MASAYOSHI;TAKAHASHI, YUICHI |
分类号 |
C12N15/113;A61K31/713;A61K48/00;A61P43/00;C07H21/02;C12N15/09 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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