发明名称 |
PHARMACEUTICAL COMPOSITION FOR INHIBITING AUTOPHAGY OF MOTOR NEURONS AND USE THEREOF |
摘要 |
A pharmaceutical composition for inhibiting the autophagy of motor neurons comprising an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound and combinations thereof:
wherein A is a C1-C5 alkyl optionally having one or more unsaturated bonds and optionally being substituted by one or more substituents selected from a group consisting of -OH, =O and C1-C3 alkyl; X is H, -OH,
Y is O or S and can optionally combine with A to form a five-membered ring; and R 1 is H or a substituted or unsubstituted C1-C20 alkyl, wherein one or more -CH 2 - of the C1-C20 alkyl are optionally being replaced by -NH- or -O-. |
申请公布号 |
EP2992879(A1) |
申请公布日期 |
2016.03.09 |
申请号 |
EP20120883034 |
申请日期 |
2012.08.17 |
申请人 |
CHINA MEDICAL UNIVERSITY |
发明人 |
LIN, SHINN-ZONG;HARN, HORNG-JYH;CHIOU, TZYY-WEN;HSUEH, KUO-WEI |
分类号 |
A61K31/192;A61K31/198;A61K31/365;A61K31/7024;A61K31/7048;A61P21/04;A61P25/00;A61P25/14 |
主分类号 |
A61K31/192 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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