Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors

摘要

Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.

主权项

1. A method for treating a solid tumor in an individual comprising administering to the individual in need thereof:
(a) an anti-cancer agent; and (b) an irreversible covalent inhibitor of Bruton's tyrosine kinase (Btk) having the structure:or a pharmaceutically acceptable salt thereof,wherein the solid tumor is non-small cell lung cancer.