发明名称 SARMs and method of use thereof
摘要 This invention is directed to a feed composition and method of affecting the carcass composition by increasing the lean mass, reducing the fat mass, and/or reducing the percent fat mass comprising SARM compounds.
申请公布号 US9278914(B2) 申请公布日期 2016.03.08
申请号 US201414168993 申请日期 2014.01.30
申请人 University of Tennessee Research Foundation 发明人 Dalton James T.;Miller Duane D.;Kearbey Jeffrey D.
分类号 A61K31/165;A61K31/275;C07C255/60;A23K1/16;A23K1/18 主分类号 A61K31/165
代理机构 Pearl Cohen Zedek Latzer Baratz LLP 代理人 Cohen Mark S.;Pearl Cohen Zedek Latzer Baratz LLP
主权项 1. A method of enhancing production of lean meats in a feedlot animal, a beef cattle, or a finishing livestock comprising administering a compound represented by the structure of formula IIIA: wherein Z is NO2, CN, Cl, F, Br, I, H, COR, COOH, or CONHR;Y is CF3, alkoxy, alkyl, hydroxyalkyl, alkylaldehyde, formyl, H, F, Br, Cl, I, CN, or Sn(R)3;R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;R2 is H, F, Cl, Br, I, CH3, CF3, OH, CN, NO2, NHCOCH3, NHCOCF3, NHCOR, alkyl, arylalkyl, OR, NH2, NHR, N(R)2, or SR;R3 is H, F, Cl, Br, I, CN, NO2, COR, COOH, CONHR, CF3, or Sn(R)3;Q is H, alkyl, halogen, CF3, CN, C(R)3, Sn(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OH, OR, COR, OCOR, OSO2R, SO2R, or SR;n is an integer of 1-4; andm is an integer of 1-3; or its isomer, pharmaceutically acceptable salt, pharmaceutical product, or any combination thereof.
地址 Knoxville TN US