| 发明名称 | FILIP1L nucleic acid fragments | ||
| 摘要 | A purified DOC1 polypeptide comprising a fragment of SEQ ID NO:1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting angiogenesis. A method of inhibiting tumor growth in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting tumor growth. | ||
| 申请公布号 | US9279009(B2) | 申请公布日期 | 2016.03.08 |
| 申请号 | US201313952192 | 申请日期 | 2013.07.26 |
| 申请人 | The United States of America, as represented by the Secretary of the Department of Health and Human Services | 发明人 | Libutti Steven K.;Kwon Mijung;Tandle Anita |
| 分类号 | A61K48/00;C07K14/47;G01N33/574;A61K35/13 | 主分类号 | A61K48/00 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A nucleic acid encoding a polypeptide consisting of a fragment of SEQ ID NO:1 selected from the group consisting of amino acids 1-790, 1-650, 1-512, 1-369, 65-893, 127-369, 127-442, 127-512, 127-580, 127-650, 127-720, 127-790, 127-893, 190-893, 310-893, and 369-893, or encoding a polypeptide comprising an amino acid sequence that is at least about 95% identical to the polypeptide sequence. | ||
| 地址 | Washington DC US | ||