| 发明名称 | Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field | ||
| 摘要 | The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative colitis. | ||
| 申请公布号 | US9279126(B2) | 申请公布日期 | 2016.03.08 |
| 申请号 | US201514685091 | 申请日期 | 2015.04.13 |
| 申请人 | Nogra Pharma Limited | 发明人 | Monteleone Giovanni |
| 分类号 | C07H21/04;C12N15/113;A61K38/00;A61K48/00 | 主分类号 | C07H21/04 |
| 代理机构 | Goodwin Procter LLP | 代理人 | Goodwin Procter LLP |
| 主权项 | 1. An antisense oligonucleotide against SMAD7 comprising the nucleotide sequence: 5′-GTXYCCCCTTCTCCCXYCAG-3′ (SEQ ID NO:2), wherein XY is a CG dinucleotide and wherein at least one XY comprises a methylated nitrogenous base. | ||
| 地址 | Dublin IE | ||