FGF-21 mutants comprising polyethylene glycol and uses thereof

摘要

The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides comprising extended in vivos half-lives, pharmaceutical compositions comprising FGF21 mutant polypeptides having extended in vivos half lives, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

主权项

1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide of SEQ ID NO: 4 having a lysine residue substitution at position 36 and at least one amino acid substitution that is: an arginine residue substitution at position 56, 59, 69, or 122; and wherein the isolated polypeptide comprises no more than five amino acid substitutions.