| 发明名称 | Fusion proteins and their use in the diagnosis and treatment of leishmaniasis | ||
| 摘要 | The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, particularly visceral leishmaniasis in animals such as humans and dogs. | ||
| 申请公布号 | US9279005(B2) | 申请公布日期 | 2016.03.08 |
| 申请号 | US201414286647 | 申请日期 | 2014.05.23 |
| 申请人 | Infectious Disease Research Institute | 发明人 | Bhatia Ajay;Reed Steven G. |
| 分类号 | G01N33/569;C12P21/04;A61K39/008;C07K14/44;G01N33/68;C07K16/20;A61K38/00;A61K39/00 | 主分类号 | G01N33/569 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method for detecting asymptomatic or sub-clinical Leishmania infection in a biological sample comprising: (a) contacting a biological sample with a fusion polypeptide comprising Leishmania antigens K26, K39, and K9, wherein the Leishmania antigen K26 comprises a sequence having at least 95% identity to SEQ ID NO:5, the Leishmania antigen K39 comprises a sequence having at least 95% identity to SEQ ID NO:6, and the Leishmania antigen K9 comprises a sequence having at least 95% identity to SEQ ID NO:7 ; and (b) detecting in the biological sample the presence of antibodies that bind to the fusion polypeptide, thereby detecting asymptomatic or sub-clinical Leishmania infection in the biological sample. | ||
| 地址 | Seattle WA US | ||