发明名称 Heterocyclic compounds for the inhibition of PASK
摘要 Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
申请公布号 US9278973(B2) 申请公布日期 2016.03.08
申请号 US201314438268 申请日期 2013.10.25
申请人 BIOENERGENIX LLC 发明人 McCall John;Kelly Robert C.;Romero Donna L.
分类号 A01N43/90;A61K31/519;C07D487/04 主分类号 A01N43/90
代理机构 代理人 Bennett Dennis A.;Levin Brock
主权项 1. A method for achieving an effect in a patient comprising the administration of a therapeutically effective amount of a compound having structural Formula I or a pharmaceutically acceptable salt or ester thereof, wherein: R1 is chosen from hydrogen, aryl, alkyl, arylalkyl, heteroaryl, heteroarylalkyl, and CONR10R11, any of which may be optionally substituted.R2 is chosen from aryl and heteroaryl, either of which may be optionally substituted; and R10 and R11 are each independently chosen from hydrogen, lower alkyl, aryl, or optionally, R10 and R11 can be taken together to form a heterocycloalkyl, or heteroaryl; to a patient, wherein the effect is selected from the group consisting of reduction of triglycerides, reduction of cholesterol, and reduction of hemoglobin Alc.
地址 San Francisco CA US