发明名称 |
MULTI-COMPONENT BIOLOGICAL TRANSPORT SYSTEMS |
摘要 |
Compositions and methods are provided that are useful for the delivery of therapeutic agents, including nucleic acids. The compositions comprises a non-covalent association complex of. a) a positively-charged backbone and b) at least two members selected from: I) a first negatively-charged backbone having a plurality of attached imaging molecules; ü) a second negatively-charged backbone having a plurality of attached targetting agents; üi) at least one member selected from RNA, DNA, ribozymes, modified oligonucleotides and cDNA endcoding a selected transgene; iv) DNA encoding at lest one persistence factor; and v) a third negatively-charged backbone having a plurality of attached biological agents; wherein the association complex carries a net positive charge and at least one of the two members from group b) is selected from I) iii) or v). |
申请公布号 |
CA2797652(C) |
申请公布日期 |
2016.03.08 |
申请号 |
CA20012797652 |
申请日期 |
2001.07.20 |
申请人 |
REVANCE THERAPEUTICS, INC. |
发明人 |
WAUGH, JACOB;DAKE, MICHAEL |
分类号 |
C07K19/00;C12N15/09;A61K38/00;A61K38/28;A61K39/385;A61K45/00;A61K47/42;A61K47/48;A61K48/00;A61K49/14;A61P3/10;A61P43/00;C07K7/00;C07K14/00;C07K14/16;C07K17/08;C12N15/87 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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