| 主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,wherein:
A is B is Z1 is independently selected at each occurrence from O, S, NH or CH2, Z2 is independently selected at each occurrence from N or CH, wherein A and B are each independently optionally substituted with one or more RA; D is C3-C10carbocycle or 3- to 10-membered heterocycle, and is optionally substituted with one or more RA; or D is selected from C1-C6alkyl, C2-C6alkenyl or C2-C6alkynyl, and is optionally substituted with one or more substituents selected from halogen, RT, —O—RS, —S—RS, —N(RSRS′), —OC(O)RS, —C(O)ORS, nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano; X is N; L1 and L2 are —(CH2)—, and are each independently optionally substituted with one or more substituents selected from halogen, RT, —O—RS, —S—RS, —N(RSRS′), —OC(O)RS, —C(O)ORS, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; L3 is bond; Y is selected from —C(R1R2)N(R5)-T-RD Or —C(R3R4)C(R6R7)-T-RD; R1 is RC, and R2 and R5, taken together with the atoms to which they are attached, form a 3- to 8-membered heterocyclic ring which is optionally substituted with one or more RA; R3 and R6 are each independently RC, and R4 and R7, taken together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic or heterocyclic ring which is optionally substituted with one or more RA; Z is selected from —C(R8R9)N(R12)-T-RD or —C(R10R11)C(R13R14)-T-RD; R8 is RC, and R9 and R12, taken together with the atoms to which they are attached, form a 3- to 8-membered heterocyclic ring which is optionally substituted with one or more RA; R10 and R13 are each independently RC, and R11 and R14,taken together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic or heterocyclic ring which is optionally substituted with one or more RA; T is each independently selected at each occurrence from a bond, -LS-, -LS-M-LS′-, -LS-M-LS′-M′-LS″-, wherein M and M′ are each independently selected at each occurrence from a bond, —O—, —S—, —N(RB)—, —C(O)—, —S(O)2—, —S(O)—, —OS(O)—, —OS(O)2—, —S(O)2O—, —S(O)O—, —C(O)O—, —OC(O)—, —OC(O)O—,—C(O)N(RB)—, —N(RB)C(O)—, —N(RB)C(O)O—, —OC(O)N(RB)—, —N(RB)S(O)—, —N(RB)S(O)2—, —S(O)N(RB)—, —S(O)2N(RB)—, —C(O)N(RB)C(O)—, —N(RB)C(O)N(RB′)—, N(RB)SO2N(RB′)—, —N(RB)S(O)N(RB′)—, C3-C10carbocycle, or 3- to 10-membered heterocycle, and wherein said C3-C10carbocycle and 3- to 10-membered heterocycle are each independently optionally substituted at each occurrence with one or more RA; RA is independently selected at each occurrence from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, -LA, or -LS-RE; RB and RB′ are each independently selected at each occurrence from hydrogen or RF; RC is independently selected at each occurrence from hydrogen, halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, or RF; RD is each independently selected at each occurrence from hydrogen or RA; RE is independently selected at each occurrence from —O—RS, —S—RS, —C(O)RS, —OC(O)RS, —C(O)ORS, —N(RSRS′),—S(O)RS, —SO2RS, —C(O)N(RSRS′), —N(RS)C(O)RS′,—N(RS)C(O)N(RS′RS″), —N(RS)SO2RS′, —SO2N(RSRS′), —N(RS)SO2N(RS′RS″), —N(RS)S(O)N(RS′RS″), —OS(O)—RS, —OS(O)2—RS, —S(O)2ORS, —S(O)2ORS, —OC(O)ORS, —N(RS)C(O)ORS′, —OC(O)N(RSRS′), —N(RS)S(O)—RS′, —S(O)N(RSRS′), —C(O)N(RS)C(O)—RS′, C3-C10carbocyclyl, or 3- to 10-membered heterocyclyl, wherein said C3-C10carbocyclyl and 3- to 10-membered heterocyclyl are each independently optionally substituted at each occurrence with one or more substituents selected from halogen, RT, —O—RB, —S—RB, —N(RBRB′),—OC(O)RB, —C(O)ORB, nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano; RF is independently selected at each occurrence from C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6carbocyclyl, C3-C6carbocyclylC1-C6alkyl, 3- to 6-membered heterocyclyl or (3- or 6-membered heterocyclyl)C1-C6alkyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; LA is independently selected at each occurrence from C1-C6alkyl, C2-C6alkenyl, or C2-C6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, RT, —O—RS, —S—RS, —N(RSRS′), —OC(O)RS, —C(O)ORS, nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano; LS, LS′ and LS″ are each independently selected at each occurrence from a bond; or C1-C6alkylene, C2-C6alkenylene, or C2-C6alkynylene, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, RT, —O—RS, —S—RS, —N(RSRS′), —OC(O)RS, —C(O)ORS, nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano; RS, RS′ and RS″ are each independently selected at each occurrence from hydrogen or RT; RT is independently selected at each occurrence from C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6carbocyclyl, C3-C6carbocyclylC1-C6alkyl, 3- to 6-membered heterocyclyl, or (3- or 6-membered heterocyclyl)C1-C6alkyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, RF, —O—RB, —S—RB, —N(RBRB′), —OC(O)RB,—C(O)ORB, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano. |
